|Year : 2019 | Volume
| Issue : 3 | Page : 109-110
Tracheal Ulceration in Dettol Poisoning
Mansoor C Abdulla
Department of General Medicine, M E S Medical College, Perinthalmanna, Kerala, India
|Date of Submission||19-Jan-2019|
|Date of Acceptance||11-Nov-2019|
|Date of Web Publication||28-Oct-2020|
Prof. Mansoor C Abdulla
Department of General Medicine, M E S Medical College, Perinthalmanna, Kerala
Dettol a mixture of 4.8% chloroxylenol, 9% pine oil, and 12% isopropyl alcohol, is a popular household disinfectant. Serious complications of Dettol poisoning include aspiration, pneumonia, adult respiratory distress syndrome, shock, acute coronary syndrome, and cardiopulmonary arrest. We report a patient with Dettol poisoning who developed tracheal ulceration complicated by diffuse subcutaneous emphysema bilateral pneumothorax and pneumomediastinum. To the best of our knowledge, tracheal ulceration following Dettol poisoning was not reported previously.
Keywords: Tracheal ulceration, dettol poisoning, pneumothorax
|How to cite this article:|
Abdulla MC. Tracheal Ulceration in Dettol Poisoning. J Transl Crit Care Med 2019;1:109-10
| Introduction|| |
Dettol (4.8% chloroxylenol, pine oil, isopropyl, and alcohol), a common household disinfectant, can cause central nervous system depression and corrosion of the oral mucosa, larynx, and the gastrointestinal tract. Serious complications after Dettol ingestion include; aspiration of Dettol with gastric contents, resulting in pneumonia, cardiopulmonary arrest, bronchospasm, adult respiratory distress syndrome (ARDS), and severe laryngeal edema with upper airways obstruction.
| Case Report|| |
An 80-year-old woman was admitted following deliberate self-harm consuming around 100 ml Dettol (4.8% chloroxylenol, pine oil, isopropyl, and alcohol). She had severe depression for 20 years and was on treatment with selective serotonin reuptake inhibitor. She was taken to a nearby hospital where she developed cardiorespiratory arrest and was intubated and mechanically ventilated. The same day she was shifted to our hospital for further medical care.
On examination, she was unconscious (FOUR Score– 5/17), had diffuse subcutaneous emphysema, tachycardia with low volume pulse, hypotension, and the breath sounds were diminished in intensity bilaterally in the infra-axillary and infrascapular regions.
Hemoglobin was 13.5 g/dl, total leukocyte count 38,400/ml with 90% neutrophils, platelet count 2, 30,000/μl, erythrocyte sedimentation rate 70 mm in1 h, and c-reactive protein was high. Blood chemistries were normal. Chest X-ray showed bilateral pneumothorax, pneumomediastinum, and subcutaneous emphysema [Figure 1]. Blood and urine cultures were sterile. Computed tomogram of the thorax showed bilateral moderate pneumothorax, pneumomediastinum, extensive surgical emphysema, and two large posterior defects in tracheal wall measuring 12 mm and 10 mm in craniocaudal dimension [Figure 2].
|Figure 1: Chest X-ray showing bilateral pneumothorax, pneumomediastinum, and subcutaneous emphysema|
Click here to view
|Figure 2: Computed tomogram of the thorax showing bilateral moderate pneumothorax, pneumomediastinum, extensive surgical emphysema, and two large posterior defects in tracheal wall measuring 12 mm and 10 mm in craniocaudal dimension|
Click here to view
Bilateral intercostal drains were kept and manual positive pressure ventilation was continued. She was started on piperacillin-tazobactum and amikacin and was continued on inotropic support with dopamine and noradrenaline. However, unfortunately, she succumbed to her illness on the second day of admission.
| Discussion|| |
Dettol, a mixture of 4.8% chloroxylenol, 9% pine oil, and 12% isopropyl alcohol, is a popular household disinfectant. The clinical presentation varies based on the amount of ingested. Dettol can cause central nervous system depression ranging from drowsiness to coma, irritation or corrosion of the aerodigestive tract, aspiration, pneumonia, ARDS, as well as cardiopulmonary arrest., Upper airway obstruction is of particular concern as it is immediately life-threatening. Serious complications include aspiration, pneumonia, ARDS, shock, acute coronary syndrome, and cardiopulmonary arrest.
The local irritative and corrosive effects on the aerodigestive tract usually cause gastrointestinal upset and localized throat pain.
The patient developed tracheal erosion after Dettol ingestion possibly secondary to the corrosive effect. The already damaged trachea due to Dettol was further injured mechanically following endotracheal intubation in our case. Tracheal rupture after endotracheal intubation is extremely rare, with a reported incidence of approximately 0.005%. Mechanical, anatomical, and individual factors are the proposed factors, which may contribute to the tracheal damage. Mechanical factors include trauma during intubation, over inflation of the cuff and vigorous coughing.
The risk of serious complications and mortality following Dettol ingestion has been reported to be around 8% and 1.8%, respectively. Mortality in patients with Dettol poisoning is commonly secondary to aspiration. Patients with Dettol poisoning have been observed to develop sudden upper airway obstruction, which can require emergent endotracheal intubation. Prognosis is good in patients who have not aspirated. Chloroxylenol is phenol and is chemically related to the other phenolic disinfectants such as carbolic acid and cresols. Pine oil is made of secondary and tertiary terpene alcohols can cause central nervous system depression along with chloroxylenol and isopropyl alcohol. Pine oil and chloroxylenol can cause renal failure and hepatitis.
The risk of aspiration in Dettol poisoning is 7.6%–8% and is thought to be secondary to the central nervous system depressant, corrosive effect of Dettol on the throat impairing the gag reflex, higher incidence of vomiting, and gastric lavage., Delayed upper airway obstruction even up to 48 h after hospital admission, is yet another major complication reported. Among the previously reported patients with delayed upper airway obstruction, two had erythematous vocal cords with ulcerations.,
| Conclusion|| |
We report a patient with Dettol poisoning who developed tracheal ulceration complicated by diffuse subcutaneous emphysema bilateral pneumothorax and pneumomediastinum. To the best of our knowledge, tracheal ulceration following Dettol poisoning was not reported previously.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Chan TY, Lau MS, Critchley JA. Serious complications associated with Dettol poisoning. Q J Med 1993;86:735-8.
Chan TY, CritchleyJA. Pulmonary aspiration following Dettol poisoning: The scope for prevention. Hum Exp Toxicol 1996;15:843-6.
Graham CA. Stridor after ingestion of dettol and domestos. Eur J Emerg Med 2004;11:52-4.
Borasio P, Ardissone F, Chiampo G. Post-intubation tracheal rupture. A report on ten cases. Eur J Cardiothorac Surg 1997;12:98-100.
Carbognani P, Bobbio A, Cattelani L, Internullo E, Caporale D, Rusca M. Management of postintubation membranous tracheal rupture. Ann Thorac Surg 2004;77:406-9.
Joynt GM, Ho KM, Gomersall CD. Delayed upper airway obstruction. A life-threatening complication of Dettol poisoning. Anaesthesia 1997;52:261-3.
[Figure 1], [Figure 2]