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REVIEW ARTICLE
Year : 2020  |  Volume : 2  |  Issue : 2  |  Page : 23-27

Desmopressin in Critically Ill Neurosurgical Patients: An Overview


1 Center of Biomedical Research, Faculty of Medicine, University of Cartagena, Cartagena, Colombia
2 Department of Neurosurgery, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India
3 Department of Neurology, National Institute of Mental Health and Neuro Sciences, Military Hospital Jabalpur, Madhya Pradesh, India
4 Regions Hospital, MN, USA
5 Center of Biomedical Research, Faculty of Medicine, University of Cartagena, Cartagena, Colombia; Department of Neurology, Paracelsus Medical University, Salzburg, Austria, Australia

Correspondence Address:
Dr. Luis Rafael Moscote-Salazar
Paracelsus Medical University, Salzburg
Australia
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DOI: 10.4103/jtccm.jtccm_14_20

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Severely ill neurosurgical patients are those who present with pathologies of the nervous system associated with either a high mortality or that which leaves significant sequelae in those who survive. Desmopressin is a synthetic analog of the antidiuretic hormone that is stored in neurohypophysis. Its function is to decrease urinary volume by increasing reabsorption of water in the convoluted tubules and nephron collectors, additionally increasing the expression of coagulation factor VII and the von Willebrand factor. For this reason, its usefulness in the management of various pathologies has been tested, from coagulopathies to posttraumatic and postsurgical diabetes insipidus. It contributes in improving hyponatremia and in maintaining the balance of fluids and electrolytes in traumatic brain injury and subarachnoid hemorrhage (SAH) patients. It has been additionally studied for its role in the risk of rebleeding in SAH patients and in those with coagulopathies, where its implicated mechanism of action is through platelet anti-aggregation.


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